| WR | Enunwa, Quincy | Pryor, Terrelle | ||
| WR | Anderson, Robby | Stewart, ArDarius* | Roberts, Andre | |
| WR | Kearse, Jermaine | Hansen, Chad | ||
| LT | Beachum, Kelvin | Ijalana, Ben | ||
| LG | Carpenter, James | Dozier, Dakota | ||
| C | Long, Spencer | Swanson, Travis | ||
| RG | Winters, Brian | |||
| RT | Shell, Brandon | Qvale, Brent | ||
| TE | Leggett, Jordan | Herndon, Chris | Tomlinson, Eric | |
| QB | McCown, Josh | Darnold, Sam | Bridgewater, Teddy | |
| RB | Crowell, Isaiah | Powell, Bilal | Cannon, Trenton | *McGuire, Elijah |
| FB | Flowers, Dimitri | |||
| DE | Williams, Leonard | Cooper, Xavier | ||
| NT | McLendon, Steve | Fatukasi, Foley | ||
| DE | Anderson, Henry | Shepherd, Nathan | ||
| OLB | Jenkins, Jordan | Martin, Josh | Mauldin, Lorenzo | |
| ILB | Williamson, Avery | Minter, Kevin | ||
| ILB | Lee, Darron | Pierre-Louis, Kevin | ||
| OLB | Donahue, Dylan | Bass, David | ||
| CB | Claiborne, Morris | Nickerson, Parry | Roberts, Darryl | |
| SS | Adams, Jamal | Brooks, Terrence | ||
| FS | Maye, Marcus | Miles, Rontez | ||
| CB | Johnson, Trumaine | Skrine, Buster | ||
| P | Edwards, Lachlan | |||
| K | Santos, Cairo | |||
| LS | Hennessy, Thomas | |||
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*ArDarius Stewart is suspended for 2 games
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*Elijah McGuire broke his foot and is a candidate to start the season on IR.
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