| WR | Allen, Keenan | Williams, Mike | ||
| WR | Willia, Tyrell | Cantrell, Dylan | ||
| WR | Benjamin, Travis | Davis, Geremy | ||
| LT | Okung, Russell | Tevi, Sam | ||
| LG | Feeney, Dan | Schofield, Michael | ||
| C | Pouncey, Mike | Quessenberry, Scott | ||
| RG | Lamp, Forrest | Crabtree, Zach | ||
| RT | Barksdale, Joe | |||
| TE | Antonio Gates* | Green, Virgil | Culkin, Sean | Hunt, Cole |
| QB | Rivers, Phillip | Smith, Geno | Jones, Cardale | |
| RB | Gordon, Melvin | Ekeler, Austin | Jackson, Justin | |
| FB | Watt, Derek | |||
| DE | Bosa, Joey | Philon, Darius | Rochell, Isaac | |
| NT | Mebane, Brandon | Square, Damion | ||
| DT | Liuget, Corey* | Jones, Justin | Richardson, Steve | |
| LEO | Ingram, Melvin | |||
| MLB | Pullard, Hayes | Brown, Jatavis | Dzubnar, Nick | |
| WLB | Perryman, Denzel | White, Kyzir | ||
| OLB | Emanuel, Kyle | Nwosu, Uchenna | ||
| CB | Hayward, Casey | Brown, Tony | ||
| SS | James, Derwin | Addae, Jahleel | Jenkins, Rayshawn | |
| FS | Phillips, Adrian | Watkins, Jaylen | ||
| CB | King, Desmond | Williams, Trevor | ||
| P | Kaser, Drew | |||
| K | Sturgis, Caleb | |||
| LS | Windt, Mike | |||
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*Corey Liuget is suspended for the first 4 games
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*Obviously, projecting Gates to sign with the Chargers is speculation.
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